ateral has obtained positive results with IA delivery of LAT8881 in the rabbit collagenase model of OA

Charles River Labs have completed a model of OA in the rat in which joint pathology is induced by local injection of mono-iodoacetate (MIA)

  • LAT8881 given orally improved weight bearing on affected limb in rats at 3 and 21 days after disease induction

PDS also confirmed efficacy of oral LAT8881 in their MIA model

  • LAT8881 at 5mg/kg given orally improved weight bearing in rats on the affected limb at 14 days

LAT8881 has effects on the painful symptoms in some models of OA and may also improve the repair of damaged joint tissue